abstract：BACKGROUND AND AIMS:Encapsulating peritoneal sclerosis (EPS) is an uncommon but severe complication of peritoneal dialysis (PD). A reliable screening tool to identify patients at risk of developing or not EPS is currently not available. We aimed to evaluate whether the reduction in dialysate sodium concentration (sodiu...

journal_title：Journal of nephrology

authors： La Milia V,Longhi S,Sironi E,Pontoriero G

更新日期：2018-02-01 00:00:00

abstract：:The expansion of genomic medicine is furthering our understanding of many human diseases. This is well illustrated in the field of nephrology, through the characterization, discovery, and growing insight into various renal diseases through use of Next Generation Sequencing (NGS) technologies. This review will provide ...

journal_title：Journal of nephrology

authors： Nestor JG,Groopman EE,Gharavi AG

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Targeted screening interventions for chronic kidney disease (CKD) are increasingly being implemented in various community settings. However, the overall success of these programs is uncertain. Therefore, the aim of this review is to determine whether targeted screening is effective in detecting people with u...

journal_title：Journal of nephrology

authors： Gheewala PA,Zaidi STR,Jose MD,Bereznicki L,Peterson GM,Castelino RL

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Previous in vitro experiments of human polycystic kidney disease (PKD) cells reported that caffeine is a risk factor for the promotion of cyst enlargement in patients with autosomal dominant PKD (ADPKD). The relentless progression of ADPKD inclines the majority of physicians to advocate minimization of caffe...

journal_title：Journal of nephrology

authors： Girardat-Rotar L,Puhan MA,Braun J,Serra AL

更新日期：2018-02-01 00:00:00

abstract：AIMS:Nonsteroidal anti-inflammatory drugs (NSAIDs) are the cornerstone of pain management. There are no detailed data on NSAIDs use in Poland, especially in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the frequency, circumstances, and causes of NSAIDs use as well as knowledge of th...

journal_title：Journal of nephrology

authors： Heleniak Z,Cieplińska M,Szychliński T,Rychter D,Jagodzińska K,Kłos A,Kuźmiuk I,Tylicka MJ,Tylicki L,Rutkowski B,Dębska-Ślizień A

更新日期：2017-12-01 00:00:00

abstract：:Toll-like receptors (TLRs) are a class of receptors of the innate immune system which detect pathogen-associated and danger-associated molecular patterns in order to initiate an inflammatory response. TLR2 and TLR4 downward signaling causes the production of proinflammatory cytokines that can induce insulin resistance...

journal_title：Journal of nephrology

authors： Garibotto G,Carta A,Picciotto D,Viazzi F,Verzola D

更新日期：2017-12-01 00:00:00

abstract：:Diabetic nephropathy (DN) is a common complication of Diabetes Mellitus (DM) Types 1 and 2, and prevention of end stage renal disease (ESRD) remains a major challenge. Despite its high prevalence, the pathogenesis of DN is still controversial. Initial glomerular disease manifested by hyperfiltration and loss of glomer...

journal_title：Journal of nephrology

authors： Zeni L,Norden AGW,Cancarini G,Unwin RJ

更新日期：2017-12-01 00:00:00

abstract：:The partial correction of anemia and the normalization of phosphate and blood pressure are the mainstay of treatment of patients with chronic kidney disease (CKD). Available anti-hypertensive drugs, erythropoiesis stimulating agents (ESAs) and iron supplements have resolved quite satisfactorily the goal of controlling...

journal_title：Journal of nephrology

authors： Locatelli F,Del Vecchio L

更新日期：2017-12-01 00:00:00

abstract：:During peritoneal dialysis (PD), peritoneal mesothelial cells undergo a transition from an epithelial phenotype to a mesenchymal phenotype that, together with the inflammatory process, promotes tissue fibrosis and a failure of peritoneal membrane function. To date, there is no definitive treatment for the progressive ...

journal_title：Journal of nephrology

authors： Lupinacci S,Toteda G,Vizza D,Perri A,Benincasa C,Mollica A,La Russa A,Gigliotti P,Leone F,Lofaro D,Bonofiglio M,Perri E,Bonofiglio R

更新日期：2017-12-01 00:00:00

abstract：:Osteoporosis and chronic kidney disease (CKD) have both independently important potential impact on bone health. A significant number of patients with CKD stages 3a-5D have been shown to have low bone mineral density (BMD), leading to a strikingly elevated risk of fractures (mainly hip fractures) and higher associated...

journal_title：Journal of nephrology

authors： Bover J,Bailone L,López-Báez V,Benito S,Ciceri P,Galassi A,Cozzolino M

更新日期：2017-10-01 00:00:00

abstract：:Preeclampsia (PE) is a protean syndrome causing a transitory kidney disease, characterised by hypertension and proteinuria, ultimately reversible after delivery. Its prevalence is variously estimated, from 3 to 5% to 10% if all the related disorders, including also pregnancy-induced hypertension (PIH) and HELLP syndro...

journal_title：Journal of nephrology

authors： Piccoli GB,Cabiddu G,Castellino S,Gernone G,Santoro D,Moroni G,Spotti D,Giacchino F,Attini R,Limardo M,Maxia S,Fois A,Gammaro L,Todros T,Kidney and Pregnancy Study Group of Italian Society of Nephrology.

更新日期：2017-06-01 00:00:00

abstract：:Inherited distal renal tubular acidosis (dRTA) is caused by impaired urinary acid excretion resulting in hyperchloremic metabolic acidosis. Although the glomerular filtration rate (GFR) is usually preserved, and hypertension and overt proteinuria are absent, it has to be considered that patients with dRTA also suffer ...

journal_title：Journal of nephrology

authors： Seeger H,Salfeld P,Eisel R,Wagner CA,Mohebbi N

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Patients undergoing chronic hemodialysis (HD) are at increased risk for peripheral artery disease (PAD). Both ankle-brachial index (ABI) and ambulatory blood pressure monitoring (ABPM) in the interdialytic period have been shown to be strong predictors of all-cause mortality. METHODS:This cross-sectional st...

journal_title：Journal of nephrology

authors： Viazzi F,Leoncini G,Ratto E,Storace G,Gonnella A,Garneri D,Bonino B,Cappadona F,Parodi EL,Verzola D,Garibotto G,Pontremoli R

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Chronic kidney disease (CKD) progression is associated with significant comorbidities and costs. In Italy, limited evidence of healthcare resource consumption and costs is available. We therefore aimed to investigate the direct healthcare costs in charge to the Lombardy Regional Health Service (RHS) for the ...

journal_title：Journal of nephrology

authors： Roggeri A,Roggeri DP,Zocchetti C,Bersani M,Conte F,ReNe (Renal Lombardy Network).,Additional contributors from ReNe Network.

更新日期：2017-04-01 00:00:00

abstract：:The study was conducted to determine the association between mortality, rurality, and distance from the treatment facility of the patients with ESRD. The United States Renal Data System (USRDS) for the year 2007-08 was utilized to conduct analysis of 181,349 subjects. After adjusting for all other covariates, the odds...

journal_title：Journal of nephrology

authors： Ajmal F,Bennett KJ,Probst JC

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Benefits and risks of angiotensin converting enzyme inhibitors (ACE-I) in advanced chronic kidney disease (CKD) are controversial. We tested the role of ACE-I in slowing the progression of renal damage in a real-world elderly population with CKD stage 5. METHODS:We evaluated all patients consecutively refer...

journal_title：Journal of nephrology

authors： Dattolo PC,Gallo P,Michelassi S,Paudice N,Cannavò R,Romoli E,Fani F,Tsalouchos A,Mehmetaj A,Ferro G,Sisca S,Pizzarelli F

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Reduction of intestinal load of phosphorus is important for the prevention and treatment of chronic kidney disease (CKD)-mineral and bone disorder (MBD). However, this strategy is limited by patients' poor adherence to dietary prescription and by the existence of hidden sources of phosphorus. In add...

journal_title：Journal of nephrology

authors： Cupisti A,Moriconi D,D'Alessandro C,Verde F,Marchini M,Saba A,Egidi MF

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Dialysis-requiring acute kidney injury (D-AKI) is common in hospitalized patients. Many patients survive the immediate post AKI period, thus at risk of suffering long-term sequelae of AKI. Prior studies examining long term outcomes lack non-dialyzed AKI control groups. Without non-dialyzed AKI control group,...

journal_title：Journal of nephrology

authors： Omotoso BA,Abdel-Rahman EM,Xin W,Ma JZ,Scully KW,Arogundade FA,Balogun RA

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:In the general population and in hemodialysis patients epicardial adipose tissue (EAT) has been associated with increased mortality and cardiovascular events. Weight loss and lipid lowering therapies reduced EAT in the general population. It is unknown whether sevelamer, a phosphate (Pi) binder that lowers c...

journal_title：Journal of nephrology

authors： Ko SM,Zhang C,Chen Z,D'Marco L,Bellasi A,Stillman AE,Block G,Raggi P

更新日期：2016-10-01 00:00:00

abstract：:In this paper we concentrate on the role of infections in IgA nephropathy both from a pathogenetic and clinic point of view. The current hypotheses as regards the role of infections in the pathogenesis of IgA nephropathy are: (a) role of particular pathogens, (b) chronic exposure to mucosal infections, (c) abnormal ha...

journal_title：Journal of nephrology

authors： Rollino C,Vischini G,Coppo R

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:There is growing evidence of the potential properties of nitrate-rich foods against development of hypertension (HTN) and vascular disease. In this study, we investigated the association of nitrate-containing vegetables (NCVs) with risk of HTN after 3 years of follow-up. METHODS:This prospective study was c...

journal_title：Journal of nephrology

authors： Golzarand M,Bahadoran Z,Mirmiran P,Zadeh-Vakili A,Azizi F

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Medullary cystic kidney disease type 1 (MCKD1; OMIM #174000) is a familial progressive tubule-interstitial nephropathy belonging to the recently defined group of autosomal dominant tubulointerstitial kidney diseases (ADTKD). CASE REPORT:A specific type of cytosine insertion in the extracellular variable n...

journal_title：Journal of nephrology

authors： Musetti C,Babu D,Fusco I,Mellone S,Zonta A,Quaglia M,Cantaluppi V,Stratta P,Giordano M

更新日期：2016-06-01 00:00:00

abstract：AIM:The objective of this study was to determine whether the baseline estimated glomerular filtration rate (eGFR) level was independently associated with in-hospital mortality in generalized patients with hospital-acquired acute kidney injury (HA-AKI) in China. METHODS:All of the patients admitted to a tertiary medica...

journal_title：Journal of nephrology

authors： Han YC,Tu Y,Liu H,Pan MM,Tang RN,Liu BC

更新日期：2016-06-01 00:00:00

abstract：:Appropriate timing of starting chronic dialysis in patients with advanced chronic kidney disease (CKD) under nephrology care still is undefined. We systematically reviewed the most recent studies that have compared outcomes of stage 5-CKD under conservative versus substitutive treatment. Eleven studies, most in elderl...

journal_title：Journal of nephrology

authors： Pacilio M,Minutolo R,Garofalo C,Liberti ME,Conte G,De Nicola L

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Rituximab (RTX) is approved for remission induction in ANCA associated vasculitis (AAV). However, data on use of RTX in patients with severe renal disease is lacking. METHODS:We conducted a retrospective multi-center study to evaluate the efficacy and safety of RTX with glucocorticoids (GC) with and without...

journal_title：Journal of nephrology

authors： Geetha D,Hruskova Z,Segelmark M,Hogan J,Morgan MD,Cavero T,Eriksson P,Seo P,Manno RL,Dale J,Harper L,Tesar V,Jayne DR

更新日期：2016-04-01 00:00:00

abstract：:The pathogenetic role of adiponectin (ADPN) in kidney failure is not yet elucidated, since in vitro and in vivo studies have demonstrated that ADPN exerts both anti-inflammatory and pro-inflammatory effects. Starting from our previous findings demonstrating that HK-2 cells express and secrete ADPN, in this study we in...

journal_title：Journal of nephrology

authors： Perri A,Vizza D,Lupinacci S,Toteda G,De Amicis F,Leone F,Gigliotti P,Lofaro D,La Russa A,Bonofiglio R

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:It is uncertain whether increasing 25-hydroxyvitamin D (25-D) levels in chronic kidney disease (CKD) patients above those recommended by current guidelines result in progressive amelioration of secondary hyperparathyroidism. Our objective was to identify a potential therapeutic 25-D target which optimally low...

journal_title：Journal of nephrology

authors： Ennis JL,Worcester EM,Coe FL,Sprague SM

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Until now, the survival of iliac vein tunneled cuffed catheters (TCCs) used in elderly patients has not been fully investigated. Accordingly, we evaluated their use in elderly hemodialysis patients with no other venous access options. METHODS:A total of 70 elderly patients with iliac vein TCCs undergoing ch...

journal_title：Journal of nephrology

authors： Wang L,Wei F,Sun G,Chen H,Yu H,Jiang A

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Cell-free DNA (cfDNA) is present in the peritoneal effluent of stable peritoneal dialysis (PD) patients, but there are no data on cfDNA in PD patients with peritonitis. We investigated the variation of peritoneal cfDNA levels subsequent to peritonitis in PD patients. METHODS:We enrolled 53 PD patients: 30 w...

journal_title：Journal of nephrology

authors： Virzì GM,Milan Manani S,Brocca A,Cantaluppi V,de Cal M,Pastori S,Tantillo I,Zambon R,Crepaldi C,Ronco C

更新日期：2016-02-01 00:00:00

abstract：:A 64-year-old man was hospitalized in 2002 with symptoms of stupor, weakness, and renal colic. The clinical examination indicated borderline hypertension, small masses in the glutei, and polyuria. Laboratory tests evidenced high serum concentrations of creatinine, calcium, and phosphate. Imaging assessments disclosed ...

journal_title：Journal of nephrology

authors： Cirillo M,Bilancio G,Cirillo C

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Ischemia-reperfusion (IR) causes acute kidney injury (AKI), and ischemia pretreatment may exert protection. Mitogen-activated protein kinase kinase 3 (MKK3), which is involved in the signal transduction pathway in IR-induced injury, is a potential target of miR-21. We aimed to verify the targeting regulation...

journal_title：Journal of nephrology

authors： Li Z,Deng X,Kang Z,Wang Y,Xia T,Ding N,Yin Y

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Plasmin has recently been reported to be associated with renal fibrosis in experimental models, but its role in human renal diseases is unclear. METHODS:Fifty-seven patients with IgA nephropathy (IgAN) were evaluated retrospectively. Plasmin in their renal biopsy tissues was assessed by in situ zymography u...

journal_title：Journal of nephrology

authors： Uchida T,Oda T,Takechi H,Matsubara H,Watanabe A,Yamamoto K,Oshima N,Sakurai Y,Kono T,Shimazaki H,Tamai S,Kumagai H

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Cardiovascular (CV) diseases are the main cause of death in maintenance hemodialysis (MHD) patients. Muscle wasting and physical function decline are common in MHD patients, and significantly impair their quality of life. These can result from abnormalities in cardiac function, which can be further worsened ...

journal_title：Journal of nephrology

authors： Jeong JH,Wu PT,Kistler BM,Fitschen PJ,Biruete AG,Phillips SA,Ali MM,Fernhall B,Wilund KR

更新日期：2015-12-01 00:00:00

abstract：BACKGROUND:The recent multicenter, randomized, open-label INDEPENDENT study demonstrated that sevelamer improves survival in new to hemodialysis (HD) patients compared with calcium carbonate. The objective of this study was to determine the cost-effectiveness of sevelamer versus calcium carbonate for patients new to HD...

journal_title：Journal of nephrology

authors： Ruggeri M,Bellasi A,Cipriani F,Molony D,Bell C,Russo D,Di Iorio B

更新日期：2015-10-01 00:00:00

abstract：:Calciphylaxis, or calcific uremic arteriolopathy, is a vascular ossification-calcification disease involving cutaneous or visceral arterioles, with ischemic damage of the surrounding tissues, usually in the setting of chronic kidney disease. Pathogenesis is still unclear and probably comprises the participation of vas...

journal_title：Journal of nephrology

authors： Oliveira TM,Frazão JM

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Mineral and bone parameters are actively managed in end-stage renal disease (ESRD). However, whether these undergo circadian variation is not known. We investigated the circadian variation of mineral and bone parameters in patients on long-term hemodialysis. METHODS:Seventeen ESRD patients on long-term hemo...

journal_title：Journal of nephrology

authors： Trivedi H,Szabo A,Zhao S,Cantor T,Raff H

更新日期：2015-06-01 00:00:00

abstract：:In the general population, moderate exercise is associated with several health benefits including a decreased risk of obesity, coronary heart disease, stroke, certain types of cancer and all-cause mortality. In chronic kidney disease (CKD), physical inability is an independent risk of death. Health benefits of regular...

journal_title：Journal of nephrology

authors： Aucella F,Battaglia Y,Bellizzi V,Bolignano D,Capitanini A,Cupisti A

更新日期：2015-04-01 00:00:00

abstract：:Sudden cardiac death (SCD) is a major cause of concern in end stage renal disease (ESRD), contributing to 70% of cardiovascular mortality and 27% of all-cause mortality in dialysis patients. Yet its mechanisms and pathogenesis remain largely obscure. This review discusses the potential reasons for an exaggerated risk ...

journal_title：Journal of nephrology

authors： Zachariah D,Kalra PR,Roberts PR

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Pericardial effusion in uremic patients (UPE) was first described by R. Bright in 1836. It is generally agreed that patients require emergency pericardial drainage when tamponade signs are present, but in patients with no tamponade the optimal timing for drainage remains unclear. METHODS:To define patients ...

journal_title：Journal of nephrology

authors： Bataille S,Brunet P,Decourt A,Bonnet G,Loundou A,Berland Y,Habib G,Vacher-Coponat H

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Phosphorus is associated with mortality in patients with chronic kidney disease (CKD) not on dialysis, possibly through phosphorus-dependent vascular calcification. Although a phosphorus-restricted diet reduces serum phosphorus, it is unlikely that it reduces vascular calcification progression in CKD. This s...

journal_title：Journal of nephrology

authors： Russo D,Bellasi A,Pota A,Russo L,Di Iorio B

更新日期：2015-02-01 00:00:00